Key Research Areas

The BHP undertakes research in the areas of virology, molecular biology, immunology, genetics, epidemiology, clinical, and social and behavioral issues relevant to the AIDS epidemic in Botswana and southern Africa. The goal is to conduct research that is directly relevant to and useful for the Ministry of Health and providers and patients in Botswana and the region, and to do so in an ethical, collaborative manner that builds capacity and supports participant rights and well-being.

Areas Include:

  • Prevention of Mother-to-Child Transmission (PMTCT) during pregnancy and breastfeeding
  • Prevention of new adult HIV infections
  • Optimal treatment of HIV-infected children and adults
  • Identifying and characterization of acute HIV infection
  • Molecular characterization of Hepatitis B Virus in Botswana and its impact on HIV co-infection
  • Molecular epidemiology of Mycobacterium tuberculosis (Mtb) in Botswana and the impact of cART on the TB incidence
  • Human genetics and how it affects the risk of HIV infection and disease progression
  • HIV antiretroviral drug resistance and surveillance of transmitted drug resistant variants
  • Health and neurobehavioral outcomes of HIV Exposed Infected (HEI) and Uninfected (HEU) Infants and how to improve the health of HEU infants
  • Effect of very early infant treatment (and other interventions) on the HIV viral reservoir
  • How to predict the future course of the HIV epidemic
  • How to evaluate the cost-effectiveness of interventions for prevention and treatment of HIV/AIDS
  • HIV related malignancies and long-term effects of ART exposure/interphase with non-communicable diseases.